You’ve tried the pills. You’ve had the steroid shots. Maybe you’ve even debated surgery. But if your knee pain keeps coming back, it’s time for a different approach.

Platelet-Rich Fibrin (PRF) therapy uses your body’s natural healing abilities to repair damaged joints, not just mask the pain. By concentrating your own growth factors and embedding them in a fibrin scaffold, PRF stimulates long-term tissue regeneration. [1]

At PRP In Seattle, our board-certified providers specialize in precision-guided PRF injections, harnessing your body’s innate healing ability to restore comfortable movement.

The result? Less pain, improved mobility, and a chance to move freely again, without surgery or harsh medications.

What Is PRF & Why Consider It for Knee Pain?

PRF is an advanced form of platelet therapy that’s spun at lower speeds than PRP, preserving white blood cells and fibrinogen. When injected into an injured or arthritic knee, these elements create a soft fibrin scaffold that slowly releases growth factors, stimulates collagen production, calms inflammation, and encourages cartilage-protecting cells to flourish.

Three-step process

  • Blood Draw – A small vial of your blood is collected in our clinic.
  • Gentle Centrifugation – We spin it at a low speed without anticoagulants, creating a concentrated, growth-factor-rich layer.
  • Injection – Your provider injects the PRF precisely into the joint space or damaged tissue to stimulate repair.

Conditions PRF Knee Injections Can Treat 

PRF excels at addressing early to moderate problems, where sufficient cartilage and ligament structure remain for the body to rebuild. Severe bone-on-bone arthritis or advanced meniscal loss may still require surgical intervention.

  • Early- to Moderate-Stage Osteoarthritis [2]
  • Meniscus Sprains or Small Tears
  • Patellofemoral Pain (“Runner’s Knee”)
  • Post-Surgical Swelling and Partial Ligament Injuries (MCL, LCL) [3]
  • Chronic Tendinopathy Around the Kneecap or Quad [4]

Benefits of PRF Knee Injections 

PRF provides a time-released healing effect within the knee, delivering a longer biological boost than steroid or hyaluronic acid injections while avoiding cartilage-thinning side effects.

  • Drug-Free Pain Relief – Uses your own biology, not corticosteroids.
  • Cartilage Support – Growth factors nurture chondrocytes and may slow future wear. [5]
  • Less Frequent Visits – Many patients improve with one to three sessions rather than seasonal steroid cycles.
  • Minimal Downtime – Light activity within 24 hours; no lengthy rehab.
  • Low Allergic Side Effect – Completely autologous (from you, for you).

Are You a Candidate?

Not every knee needs PRF, and a careful evaluation protects you from disappointment. We will determine if you are a candidate for this treatment on your consultation day by reviewing your imaging reports, activity goals, and overall health to ensure PRF is the best next step. People who typically benefit include:

  • Adults with mild to moderate arthritis who want to delay or avoid knee replacement.
  • Athletes sidelined by chronic overuse injuries that haven’t responded to rest or therapy.
  • Post-operative patients seeking to accelerate healing and reduce lingering inflammation.

Contraindications include active infection, uncontrolled autoimmune disease, certain blood disorders, or the use of high-dose anticoagulants. 

Interested in the PRF Knee Injections?

Fill out the form below to schedule your free consultation or ask any questions you may have.

    PRF vs. Steroid & Hyaluronic-Acid Shots

    Steroid injections act fast but can thin cartilage with repeated use. Hyaluronic acid lubricates joints yet rarely lasts beyond six months. PRF, by contrast, supplies living growth factors that actively regenerate tissue and may reduce, rather than merely mask, degeneration. While each therapy has a place, PRF’s regenerative profile makes it uniquely suited for patients who value long-term joint health. [5]

    Cost of PRF Knee Injections in Seattle 

    PRF knee injection at PRP in Seattle is $650 per session. Package pricing may be available for patients who require a series of treatments. Seattle Plastic Surgery works with outside financial services, including Alphaeon and CareCredit. Our staff can help you apply for these options and provide additional information about financial assistance.

    Schedule a Consultation

    If persistent knee pain is keeping you from everyday activities, we’re here to help. Schedule a meeting with us and receive a personalized PRF treatment plan tailored to your needs. Call (206) 279-2112 or click here to book your consultation and let’s take the first step toward steadier, pain-free movement.

    FAQs 

    What is a PRF injection in the knee? 

    A PRF knee injection is an in-office treatment where your own blood is gently spun to create a platelet- and leukocyte-rich fibrin matrix; this gel is then ultrasound-guided into the joint to bathe cartilage, meniscus, and synovium in slow-release growth factors that drive repair. 

    Do PRF injections actually work? 

    Clinical data show meaningful pain and function improvements for knee-osteoarthritis patients, with one 36-month study of intra-articular PRP + i-PRF reporting sustained “satisfactory” outcomes and longer injection intervals—evidence of a disease-modifying effect rather than a short-term numbing shot. [6] 

    What are the advantages of PRF? 

    Compared with PRP, PRF is simpler to prepare (no anticoagulants), provides a fibrin scaffold for better growth-factor retention, and shows faster tissue-regeneration in head-to-head studies—benefits that translate to fewer injections and longer relief windows. [7]

    Who should not get PRF? 

    Patients with active infection, uncontrolled autoimmune disease, severe platelet disorders, or those on high-dose antiplatelet/anticoagulant therapy are generally discouraged because these factors can blunt platelet activity or raise procedural risk. 

    Are PRF results permanent? 

    Most knees stay notably better for 9–18 months (and some studies track benefit past 3 years), but cartilage and soft-tissue aging continues; booster injections are safe whenever symptoms recur.

    What is the success rate of PRF? 

    Prospective data suggest roughly 60-70 % of treated knees achieve clinically significant pain and function gains, with 3-year “survival” (no conversion to surgery) reported in the majority of cases. 

    [1] https://pubmed.ncbi.nlm.nih.gov/25690170/

    [2] https://pmc.ncbi.nlm.nih.gov/articles/PMC10302511/

    [3] https://pmc.ncbi.nlm.nih.gov/articles/PMC4660809/

    [4] https://pmc.ncbi.nlm.nih.gov/articles/PMC5004020/

    [5] https://pmc.ncbi.nlm.nih.gov/articles/PMC10687893/

    [6] https://pubmed.ncbi.nlm.nih.gov/37009386/

    [7] https://pubmed.ncbi.nlm.nih.gov/25855914/

    STILL HAVE QUESTIONS?

    Give us a call at (206) 279-2112. Chat by clicking the icon in the lower left hand corner of your screen. Otherwise, contact us by filling out the form above.